Huberman Lab Essentials

Science-Based Tools for Male Hormone Optimization

Dr. Kyle Gillett shares evidence-based strategies for optimizing male hormones through bloodwork, diet, exercise, and targeted supplementation.

Optimizing male hormones involves a combination of bloodwork analysis, nutritional adjustments, exercise, and specific supplements like creatine and Tongkat Ali, as discussed by Dr. Kyle Gillett.

123
40 minJul 2, 2026Huberman Lab

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Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett

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Key takeaways

What to know before you press play.

01

Importance of Bloodwork

Blood tests are a critical tool for assessing hormone levels and guiding optimization strategies.

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02

Nutrition and Lifestyle Impact

Diet, caloric restriction, stress management, and life purpose significantly influence hormone health.

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03

Exercise Benefits

Regular exercise is a foundational pillar for maintaining healthy hormone levels.

16
04

Supplement Strategies

Specific supplements such as creatine, L-carnitine, Tongkat Ali, and Fadogia agrestis are discussed for their potential role in hormone optimization.

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05

Medical Interventions

Testosterone replacement therapy (TRT), Clomiphene, and other medical options are considered for specific cases.

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Ask GenPod next

Keep the question moving.

01

What are the specific dosages for Tongkat Ali and Fadogia agrestis?

02

How does caloric restriction specifically impact testosterone levels?

03

What are the side effects of testosterone replacement therapy?

Background reading

The context behind the episode.

Expert Insight

Dr. Kyle Gillett's Approach

Dr. Kyle Gillett is a dual board-certified physician in family medicine and obesity medicine, specializing in hormone optimization.

1

Questions

Questions to carry into the episode.

What role does bloodwork play in hormone optimization?

Blood tests are used to assess hormone levels and guide optimization strategies.

11
How do diet and lifestyle affect hormone health?

Diet, caloric restriction, stress, and life purpose are key factors influencing hormone levels.

121314
Which supplements are recommended for testosterone support?

Creatine, L-carnitine, Tongkat Ali, and Fadogia agrestis are discussed as potential supplements.

318192123
What medical therapies are available for hormone optimization?

Testosterone replacement therapy (TRT) and Clomiphene are mentioned as medical options.

172425
How do alcohol and other factors impact testosterone?

Alcohol, aromatase activity, and other lifestyle factors can influence testosterone levels.

27

Experts

Voices named in the source.

Kyle Gillett

MD, dual board-certified physician in family medicine and obesity medicine

1

Sources and disclosure

Where this guide comes from.

This episode is part of the Huberman Lab Essentials series. Sponsors include AG1, LMNT, and David.

  1. Publisher show notes

    In this Huberman Lab Essentials episode, my guest is Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine, and an expert in hormone optimization.

  2. Publisher show notes

    We discuss science-based tools for optimizing male hormones across the lifespan, including the role of bloodwork, nutrition, and exercise in supporting healthy hormone levels.

  3. Publisher show notes

    We also discuss testosterone therapy, hair loss, prostate health, and supplements such as creatine, L-carnitine, Tongkat Ali, and Fadogia agrestis.

  4. Publisher show notes

    Read the show notes at hubermanlab.com.

  5. Publisher show notes

    Thank you to our sponsors

  6. Publisher show notes

    AG1: https://drinkag1.com/huberman

  7. Publisher show notes

    LMNT: https://drinklmnt.com/huberman

  8. Publisher show notes

    David: https://davidprotein.com/huberman

  9. Publisher show notes

    Timestamps

  10. Publisher show notes

    (00:00:00) Kyle Gillett

  11. Publisher show notes

    (00:00:20) Male Hormone Optimization, Testosterone, Tool: Blood Tests

  12. Publisher show notes

    (00:02:17) Diet & Hormone Health, Diary, Vitamin D, Fiber

  13. Publisher show notes

    (00:05:36) Caloric Restriction & Testosterone

  14. Publisher show notes

    (00:06:44) Lifestyle Pillars: Stress, Life Purpose

  15. Publisher show notes

    (00:07:56) Sponsor: LMNT

  16. Publisher show notes

    (00:09:28) Exercise & Hormone Health

  17. Publisher show notes

    (00:10:32) Testosterone Replacement Therapy (TRT) & Young Adults

  18. Publisher show notes

    (00:12:05) Supplements for Testosterone, Creatine & Hair Loss; Betaine, Doses

  19. Publisher show notes

    (00:15:50) L-Carnitine, Forms, Dose, TMAO, Garlic & Berberine

  20. Publisher show notes

    (00:19:02) Vitamin D, Boron

  21. Publisher show notes

    (00:20:43) Tongkat Ali (Longjack)

  22. Publisher show notes

    (00:23:34) Sponsor: AG1

  23. Publisher show notes

    (00:24:53) Fadogia Agrestis

  24. Publisher show notes

    (00:26:49) Testosterone Therapy, Dose; Side Effects

  25. Publisher show notes

    (00:31:24) Clomiphene, SERM & Testosterone

  26. Publisher show notes

    (00:33:58) Sponsor: David

  27. Publisher show notes

    (00:35:16) Alcohol, Aromatase & Testosterone

  28. Publisher show notes

    (00:36:09) Prostate Health & Tadalafil, Nighttime Urination

  29. Publisher show notes

    (00:38:10) Hair Loss, Caffeine, Finasteride, Dutasteride

  30. Publisher show notes

    (00:40:13) Acknowledgements

  31. Publisher show notes

    Disclaimer & Disclosures

  32. Publisher show notes

    Learn more about your ad choices. Visit megaphone.fm/adchoices

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